In the season premiere, House and Cuddy continue to work on their "confession" at the end of last season - they hope their relationship can continue. At the same time, a well-known neurosurgeon at Princeton Teaching Hospital develops an illness and has to miss several surgeries, threatening the hospital's reputation as a first-level emergency center. In order to cure this colleague as soon as possible, House's medical team thought of many ways. But they found that this colleague's problem was not just the disease, but also had a deeper reason. They asked House for help, but House, as always, ignored them and let them deal with it themselves.