The film tells the origin story of the most mysterious female superhero in Marvel Comics. Paramedic Cathy (Spider-Lady, played by Dakota Johnson) discovers that she can predict the future by accident. In the process of exploring the origin of her ability, she is closely linked to the fate of the three Spider-Women. Faced with the pursuit of the villain "Poison Spider" Ezekiel, Spider-Lady tries to find out the reason. How will they use their ability to predict the future to change the fate of the world as they travel through time?