In the Princeton University Hospital, there is a famous internist, Greg House (Hugh Laurie). He is dressed in sloppy clothes, with a cane in his hand, stubborn and sharp, and has no image of the kind of humble and rigorous professional physician in people's impression. However, under this astonishing appearance, there are superb medical skills and rich knowledge that are admired by colleagues and patients. Dr. House's treatment method is also unique. He does not consult face to face, and he absolutely does not believe the patient's feelings. Instead, he completely relies on his outstanding knowledge and superb reasoning ability to solve many difficult and complicated diseases. With the assistance of neurologist Tyler Eric Furman (Omar Epps), immunologist Allison Cameron (Jennifer Morrison), and cardiologist and emergency physician Robert Chase (Jesse Spencer), House's team shines brightly and creates medical miracles one after another...