After the fierce battle, the two Predators returned home with the bodies of their dead companions. What they could not imagine was that the bodies of their dead companions had become the habitat of alien eggs. The mature aliens broke out of their chests and possessed the powerful power of both the aliens and the Predators, becoming the ultimate aliens that even the Predators could not shake. A brutal killing took place on the spacecraft, which eventually caused the spacecraft to crash into the mountains of Colorado. The surviving aliens escaped from the spacecraft and began to reproduce horribly, and the residents of the nearby town of Connison inevitably became the targets of alien hunting and parasitism. The originally quiet and peaceful town turned into a terrifying hell on earth. At the same time, an Predator who stayed on Earth learned the message sent by his companion before his death, and he decided to fight this group of fateful demon enemies to the end...