Gangster boss Eddie King planned a murder case, which was witnessed by a young man named Sean Jones (Nathan Phillips) who happened to pass by. In order to successfully accuse this evil gangster in court, the police sent senior federal agent Neville Finn (Samuel L. Jackson) to protect Sean and escort him from Hawaii to the Los Angeles court. In order to avoid the murder of witnesses, Neville adopted a feint to the east and attacked in the west strategy, and secretly boarded an ordinary red-eye flight with Sean. However, this top-secret plan was discovered by the mole that Eddie arranged in the police. In order to escape legal sanctions, Eddie sent a killer carrying a large number of venomous snakes on the plane, and a bizarre, terrifying and bloody case of silencing unfolded...