Finally one day, humans declared war on the increasing number of vampires and werewolves. These two tribes were besieged and slaughtered, and humans gained absolute advantage. Selina (Kate Beckinsale) and John also suffered in this catastrophe. When she woke up again, she found herself imprisoned by an institution called Antigen Research Institute, numbered as Experiment No. 1. She struggled to break through the shackles and searched for Experiment No. 2, John, in the dark city based on her ability of co-vision. On the way, she encountered the help of her fellow vampires and the attack of werewolves. When she found Experiment No. 2 being chased by the werewolves, she found that she was a little girl who had never met but had extremely terrifying power-Yvie (India Eisley), who was a hybrid of the vampires and the werewolves. In this strange era, Selina is destined to continue to live a bloody life...