Private Sakura Academy was originally a girls' high school. However, under the impact of social trends, the school decided to open its doors to welcome boys. In the first year, the school admitted only 28 boys, and they had to face 524 "wolf-like" girls. Tsuda Takashi (voiced by Shintaro Asanuma) is one of the 28 people. By chance, he accidentally joined the student union. With the company of three quirky girls, including the student union president Amakusa Shino (voiced by Yoko Hikasa), who has a dignified and beautiful appearance but has a very big brain and strong delusion ability, Nanajo Tenku (voiced by Satomi Sato), who is mature and reliable but sometimes speaks out of turn, and Ogimura Suzu (voiced by Sayuri Yahagi), who has a super IQ but a personality as arrogant as an elementary school student, Tsuda's campus life officially begins.